Genomic Signature Of Membrane Permeation Induced By Intense THz PulsesPaper (Bio 1)
Wed, 11 Nov 2020 05:30pm to 05:45pm
Intense THz pulses induce large differential gene expressions in human skin that are predicted to suppress pro-mitotic signaling. Epidermal differentiation is a calcium-regulated process and excellent candidate for studying genetics of THz-induced biological effects due to the strong over-representation of THz-affected genes in these processes. Results indicate application of THz for targeted inhibition of mitotic activity in skin, and additionally suggest membrane permeation as a key mechanism of THz-induced biological effects. Preliminary experiments investigating fluorescence detection of membrane permeability in THz-exposed cell lines will be discussed.
Authors: Hough, Cameron; Purschke, David; Huang, Chenxi; Titova, Lyubov; Kovalchuk, Olga; Warkentin, Brad; Hegmann, Frank
University of Alberta, University of Lethbridge, Worcester Polytechnic Institute